The North American Menopause Society released a new position statement.

We have been advocating individualized dosing and the importance of using the smallest dose possible. Here is an excerpt:

"The lowest effective dose of estrogen consistent with
treatment goals, benefits, and risks for the individual woman
should be the therapeutic goal, with a corresponding low
dose of progestogen added to counter the adverse effects of
systemic ET on the uterus. Lower ET and EPT doses are
better tolerated and may have a more favorable benefit-risk
ratio than standard doses."